THELAB

Exploring the interplay of blood vessel,
immunology, and chronic inflammation

LABMISSION

Navigating Complexity: Merging Vascular Biology, Immunology, and Spatial Transcriptomics to Forge Scientific Progress

Welcome to InversoLab, where we explore the intricate interplay of vascular biology, immunology, and chronic inflammation. Our interdisciplinary team of scientists is dedicated to unraveling the complexities of biological processes within specific anatomical environments, driving transformative discoveries in biomedical science.

At the core of our mission lies a fusion of cutting-edge microscopy and spatially-resolved multi-omics with a traditional pathologist’s approach to biological questions, enabling us to expand the boundaries of basic and clinical understanding. We focus on deciphering how blood vessels shape organ compartmentalization and drive the progression of metabolic and viral diseases, with a particular emphasis on chronic hepatitis.

 

Central to our research is the exploration of liver lobules, the functional units of the liver. These intricate structures, defined by a unique vascular architecture, serve as the focal point for our investigations into the vascular control of chronic liver diseases. Our studies aim to decipher the complex interplay of blood vessels and immune cells within liver lobules, elucidating their critical roles in diseases like NASH (Non-alcoholic steatohepatitis) and viral hepatitis. By analyzing zonation patterns within liver lobules and investigating the interactions between vascular endothelial cells and immune cells, we gain insights into disease mechanisms and potential therapeutic targets.

 

At InversoLab, our investigation spans multiple dimensions, each revealing unique insights into the intricate workings of biological systems:

 

Mapping Gene Function in 3D uncovers the spatial organization of gene expression within tissues, a critical determinant of cellular function and identity. Leveraging state-of-the-art spatial transcriptomics technologies, we map gene expression patterns in three-dimensional space, offering unprecedented insights into tissue architecture. By integrating this spatially resolved transcriptomic data with anatomical information, we deepen our understanding of how gene expression programs shape tissue structure and function.

In tandem, we investigate the dynamic behavior of blood vessels in health and disease through Deciphering Blood Vessel Dynamics. Recognizing blood vessels as lifelines crucial for maintaining tissue homeostasis, our lab delves into the forefront of vascular biology research. Utilizing advanced imaging techniques and sophisticated computational analyses, we uncover new insights into the vascular control of organ function, shedding light on the intricate mechanisms governing blood vessel behavior.

Complementing this endeavor, Unraveling Immune Cell Signaling illuminates the complex interplay between the immune system and tissue function. As guardians against pathogens, immune cells play a pivotal role in tissue homeostasis. Our research dissects the intricate signaling pathways governing immune cell behavior and function within specific anatomical contexts. Through this exploration, we uncover novel mechanisms of immune regulation and identify targets for therapeutic intervention in diseases ranging from autoimmune disorders to cancer.

 

Check the dedicated research section for more detail about our ongoing projects.

RESEARCHERS

Our lab has six experts who use advanced imaging technology to research nanoscale phenomena.

3 ACTIVE PROJECTS

Our lab researches electron microscopy with three active projects.

15 PAPER PUBLICATIONS

Their research, presented internationally, impacts medicine, energy, and electronics, and advances material and biological sciences.