LABGROUP

Meet Our Scientific Team

Donato Inverso

Research Group Leader

Donato Inverso was originally trained as pathologist at Faculty of Veterinary Medicine (Naples, Italy), and in 2015 he obtained his PhD in basic and applied immunology “Università Vita Salute San Raffaele” (Milan, Italy).

In July 2022, he started his independent group on Vascular Pathobiology at the Division of “Immunology, Transplantation and infectious disease”, San Raffaele Scientific Institute (Milano), funded by an AIRC start-up grant and a HORIZON-2020 collaborative grant (FET-grant) and he was appointed as tenure-track professor in pathology at the Medical Faculty of the “Vita-Salute San Raffele” University.

Donato Inverso was originally trained as pathologist at Faculty of Veterinary Medicine (Naples, Italy), and in 2015 he obtained his PhD in basic and applied immunology “Università Vita Salute San Raffaele” (Milan, Italy). During his PhD training he established a correlative microscopy technique that combines the specificity of 3D confocal fluorescence microscopy with the much higher resolution (few nm instead of μm) of transmission electron microscopy. This approach, together with murine model of hepatitis B (HBV) pathogenesis, allowed for the discovery that intravascular T cells extend cellular protrusions through endothelial fenestrations to contact the hepatocyte membrane. This peculiar mechanism of antigen recognition defined a unique and novel mode of adaptive immune surveillance, that can be inhibited by the processes characterizing liver fibrosis (Cell, 2015).

In 2016, I moved to the lab of Prof. Hellmut G. Augustin in the Division of Vascular Oncology and Metastasis (DKFZ, Heidelberg), where he was awarded with an EMBO fellowship (2017-2018) and the two-year DKFZ postdoctoral fellowship (2019-2020). During this time, he worked at the interface of vascular biology and liver pathobiology. In particular, he developed a spatially-resolved FACS-sorting methodology of liver endothelial cells, drafting the first comprehensive and spatially-resolved phosphoproteome of any vascular bed (Developmental Cell, 2021).

In collaboration with Prof. Mathias Heikenwälder, Division of Chronic Inflammation and Cancer (DKFZ, Heidelberg) he focus on the immune-mediated damage of liver during non-acholic steatohepatitis (NASH). They showed that platelets anti-aggregation therapies decrease the intra-hepatic accumulation of inflammatory cells, leading to a significant reduction of the non-acholic steatohepatitis (NASH) and Hepatocellular Carcinoma (HCC) occurrence in both mouse and human (Nature Medicine, 2019). Moreover, they recently identified a new subset of auto-aggressive T cells which are responsible of the sustained liver damage during NASH (Nature, 2021 p 444-449) and do not respond to the immune-checkpoint inhibition therapy (Nature, 2021 p 450-456).

In July 2022, he started his independent group at the Division of “Immunology, Transplantation and infectious disease”, San Raffaele Scientific Institute, Milano, funded by an AIRC start-up grant and a HORIZON-2020 collaborative grant (FET-grant) and he was appointed as tenure-track professor in pathology at the Medical Faculty of the “Vita-Salute San Raffele” University.

Michele D’Antonio

Research Fellow

Michele D’Antonio obtained his master degree in Veterinary Medicine in 2022, he joined Inverso Lab as research fellow in 2022, and his research centers on elucidating the role of endothelial cells in chronic liver diseases.

Michele D’Antonio obtained his master degree in Veterinary Medicine in 2022. Michele have a well-established expertise in mouse pathology and histopathology, and on murine model of dietary induced metabolic dysfunction. He joined Inverso Lab as research fellow in 2022, and his research centers on elucidating the role of endothelial cells in chronic liver diseases, including NASH, HCC, and HBV infection.

Monica Giannotta

Senior Post-Doctoral Researcher

Monica is a experienced scientist specializing in vascular biology. In 2022, Monica assumed the role of Senior Post-Doctoral Researcher at Inverso Lab, focusing on investigating the vascular mechanisms governing liver regeneration and the progression of NASH.

Monica Giannotta is a experienced scientist with a decade-long tenure in Elisabetta de Jana’s distinguished laboratory, specializing in vascular biology. Her expertise spans endothelial cell culture, advanced imaging, protein biochemistry, mouse handling, and omics technologies. She holds significant recognition for her work on diverse organotypic vasculatures, notably brain and lung endothelial cells. In 2022, Monica assumed the role of Senior Post-Doctoral Researcher at Inverso Lab, focusing on investigating the vascular mechanisms governing liver regeneration and the progression of NASH.